- Anti-oxidant/anti-inflamatory nanoparticles to protect the brain from excess electrophysiology and to mitigate damage post-crisis
- Characterization of the didys552 zebrafish mutant line (mutation in snc1lab gene) and set up of an efficacy drug screening assay using reference compounds
- Cell Therapy with GABAergic interneuron precursors for Early Infantil Epileptic Encephalopathies (S. Dravet, S. West y S. Stxbp1)
- Creation of a therapeutic drug monitoring (TDM) unit for the optimization of the Dravet syndrome pharmacological therapy
- Design, synthesis and pharmacological evaluation of new neuroprotective agents oriented to the tratment of Dravet syndrome
- Efecto de campos magnéticos estáticos de intensidad moderada en modelos de epilepsia y síndrome de Dravet
- The effect of beta-caryophyllene treatment in a murine model of Dravet syndrome
- The endocannabinoid system study in Dravet syndrome
- Intrinsic neuronal excitability and spontaneous 1 activity underlie cortical abnormalities upon Nr2f1/COUP-TFI deficiency
- Investigating Epilepsy by Super-resolution Imaging of Synapses and the Extracellular Space in Live Brain Tissue
- Precision Medicine in Dravet Syndrome
- Reactive Neurogenesis and Gliogenesis in a Dravet Syndrome Mouse Model
(The Neural Stem Cell and Neurogenesis Lab)
(The Neural Stem Cell and Neurogenesis Lab)
Timeline: 4 years.
Project costs: €400.000
Fundraise: €20.000
Juan Manuel Encinas
IKERBASQUE Research Professor
Laboratory of Neural Stem Cells and Neurogenesis
Achucarro Basque Center for Neuroscience
Edif. Sede. Campus UPV/EHU. Barrio Sarriena s/n.
E-48940 Leioa (Bizkaia, España)
1. To analyze:
A) Alterations in hippocampal neurogenesis (reactive neural stem cells; aberrant newborn neurons);
B) Reactive gliosis (neuronal death, astrogliogenesis, microgliosis, inflammation, blood brain barrier…).
2. To explore novel therapeutic strategies acting on neural stem cells, newborn neurons, glia and inflammation.
Personnel (postdoc, part-time technician); Dravet Syndrome transgenic mouse colony. Equipment and Achucarro and UPV/EHU) services (imaging, genomic expression, proteoics…). Disposable materials and reagents.